{"schema_version":"secwatch.filing_event.v1","accession":"0001628280-23-018552","form_type":"8-K","ticker":"PRME","cik":"0001894562","company_name":"Prime Medicine, Inc.","filed_at":"2023-05-17T23:59:59+00:00","discovered_at":"2026-05-14T18:03:41.530361+00:00","generated_at":"2026-06-14T22:41:07.536291+00:00","sec_items":["7.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.65,"calibrated_materiality_score":0.65,"confidence":"high","headline":"Prime Medicine presents preclinical data on CGD correction and PASSIGE CAR-T platform at ASGCT","bullets":["Prime editing corrected CGD mutation in >90% of CD34+ cells from four donors with no off-target edits detected.","Long-term engraftment >92% editing in vivo supports PM359 advancement as CGD treatment candidate.","PASSIGE platform inserted CD19 CAR (3.5 kb) at TRAC locus in 60% of T cells, with >90% TCR loss.","PASSIGE-generated CAR-T cells showed potent anti-tumor activity in vitro and in vivo.","Multiplex prime editing achieved >90% B2M knockout in primary T cells, enabling allogeneic CAR-T potential."],"urls":{"canonical":"https://secwatch.observer/filing/0001628280-23-018552","json":"https://secwatch.observer/filing/0001628280-23-018552.json","markdown":"https://secwatch.observer/filing/0001628280-23-018552.md","text":"https://secwatch.observer/filing/0001628280-23-018552.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1894562/000162828023018552/0001628280-23-018552-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1894562/000162828023018552/prme-20230517.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-14T22:41:07.536291+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}