other material
confidence high
sentiment positive
materiality 0.90
MoonLake's sonelokimab hits HiSCR75 with 29 ppt delta (p=0.0002) in Phase 2 HS trial
MoonLake Immunotherapeutics
- Primary endpoint HiSCR75 met with 29 ppt delta vs placebo (p=0.0002) at week 12.
- HiSCR50 achieved 38 ppt delta (p<0.0001), highest delta observed for any molecule in HS.
- Secondary endpoints including HiSCR90, IHS4, and patient-reported pain/quality of life met statistical significance.
- Safety profile consistent with known IL-17 inhibitor class; no new safety signals observed.
- Dose of 120mg performed similarly to 240mg; 120mg considered optimal for further development.