other material
confidence high
sentiment negative
materiality 0.80
C4 Therapeutics discontinues CFT8634 BRD9 degrader; Q3 net loss $27.0M
C4 Therapeutics, Inc.
- CFT8634 Phase 1 dose escalation failed to show sufficient single-agent efficacy in synovial sarcoma and SMARCB1-null tumors despite high BRD9 degradation; wind-down by Q1 2024.
- Net loss $27.0M ($0.55 per share) vs $32.0M ($0.65) in Q3 2022; revenue $11.1M (up from $6.8M) from Roche and Biogen collaborations.
- Cash, equivalents and marketable securities $246.4M as of Sept 30, 2023; expected runway into H2 2025.
- CFT7455 Phase 1 dose escalation completed in monotherapy for R/R MM; combination arm continues; virtual event on Dec 12, 2023.
- Kendra Adams appointed CFO in September 2023.