---
schema_version: "secwatch.filing_event.v1"
accession: "0001628280-26-025508"
form_type: "8-K"
ticker: "SYRE"
cik: "0001636282"
company_name: "Spyre Therapeutics, Inc."
filed_at: "2026-04-16T23:59:59+00:00"
generated_at: "2026-05-15T05:47:18.729716+00:00"
event_type: "other_material"
sentiment: "neutral"
materiality_score: 0.7
calibrated_materiality_score: 0.7
confidence: "high"
source: SEC EDGAR
---

# Spyre Therapeutics raises ~$463.5M in underwritten public offering of 7.475M shares at $62.00/share

## Summary
- Gross proceeds of ~$463.5M from 7.475M shares including full exercise of over-allotment option at $62.00/share.
- Proceeds to fund IBD and rheumatic disease programs, including preclinical, clinical trials, manufacturing, and Phase 3 readiness.
- Underwriting agreement with Jefferies, Goldman Sachs, Evercore, and Guggenheim Securities as representatives.
- Offering closed on April 16, 2026.

## SEC filing metadata
- accession: 0001628280-26-025508
- form_type: 8-K
- ticker: SYRE
- cik: 0001636282
- company_name: Spyre Therapeutics, Inc.
- filed_at: 2026-04-16T23:59:59+00:00
- event_type: other_material
- sentiment: neutral
- materiality_score: 0.7
- calibrated_materiality_score: 0.7
- confidence: high
- sec_items: 1.01, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1636282/000162828026025508/0001628280-26-025508-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1636282/000162828026025508/syre-20260414.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001628280-26-025508
- JSON: https://secwatch.observer/filing/0001628280-26-025508.json
- Plain text: https://secwatch.observer/filing/0001628280-26-025508.txt

## Source-grounded claims
- claim_id: d9ca047cbe049c56a5dfea7b8af40c69f6176cf6
  claim: Spyre Therapeutics, Inc. entered into Underwriting Agreement with Jefferies LLC, Goldman Sachs & Co. LLC, Evercore Group L.L.C. and Guggenheim Securities, LLC, as the representatives of the underwriters valued at approximately $463.5 million (effective 2026-04-14).
  evidence_excerpt: The Underwriting Agreement contains customary representations and warranties, agreements and obligations, conditions to closing and termination provisions.
  evidence_url: https://www.sec.gov/Archives/edgar/data/1636282/000162828026025508/0001628280-26-025508-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.