{"schema_version":"secwatch.filing_event.v1","accession":"0001628280-26-028876","form_type":"8-K","ticker":"CTNM","cik":"0001855175","company_name":"Contineum Therapeutics, Inc.","filed_at":"2026-04-30T23:59:59+00:00","discovered_at":"2026-05-14T18:02:33.149043+00:00","generated_at":"2026-05-15T01:07:47.663301+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.7,"calibrated_materiality_score":0.7,"confidence":"high","headline":"Contineum PIPE-791 Phase 1b shows safety, numeric pain reduction vs placebo","bullets":["43-patient crossover trial met primary safety endpoint; no serious AEs, most common TEAEs: headache (n=3), fatigue (n=2).","COAP patients: mean PI-NRS change -1.60 (PIPE-791) vs -1.27 (placebo) in Treatment Period 1.","CLBP patients: mean PI-NRS change -1.33 (PIPE-791) vs -0.55 (placebo) in Treatment Period 1.","Exploratory endpoints (≥30% pain reduction, KOOS) further supported positive PI-NRS trends.","Company plans further evaluation of PIPE-791 for chronic pain; also in Phase 2 PROPEL-IPF (IPF)."],"urls":{"canonical":"https://secwatch.observer/filing/0001628280-26-028876","json":"https://secwatch.observer/filing/0001628280-26-028876.json","markdown":"https://secwatch.observer/filing/0001628280-26-028876.md","text":"https://secwatch.observer/filing/0001628280-26-028876.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1855175/000162828026028876/0001628280-26-028876-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1855175/000162828026028876/ctnm-20260430.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-15T01:07:47.663301+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}