---
schema_version: "secwatch.filing_event.v1"
accession: "0001628280-26-063369"
form_type: "8-K"
ticker: "SNTI"
cik: "0001854270"
company_name: "Senti Biosciences, Inc."
filed_at: "2026-09-24T20:03:57+00:00"
generated_at: "2026-09-24T20:05:31.146531+00:00"
event_type: "leadership"
sentiment: "neutral"
materiality_score: 0.25
calibrated_materiality_score: 0.25
confidence: "high"
source: SEC EDGAR
---

# Senti Biosciences board member Brenda Cooperstone resigns effective immediately

## Summary
- Brenda Cooperstone, Ph.D. resigned from the Board on September 23, 2026, effective immediately.
- Cooperstone also stepped down as Chair of the Compensation Committee, effective immediately.
- Resignation was not due to any disagreement with Senti on operations, policies, or practices.

## SEC filing metadata
- accession: 0001628280-26-063369
- form_type: 8-K
- ticker: SNTI
- cik: 0001854270
- company_name: Senti Biosciences, Inc.
- filed_at: 2026-09-24T20:03:57+00:00
- event_type: leadership
- sentiment: neutral
- materiality_score: 0.25
- calibrated_materiality_score: 0.25
- confidence: high
- sec_items: 5.02
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1854270/000162828026063369/0001628280-26-063369-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1854270/000162828026063369/snti-20260923.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001628280-26-063369
- JSON: https://secwatch.observer/filing/0001628280-26-063369.json
- Plain text: https://secwatch.observer/filing/0001628280-26-063369.txt

## Key facts
- Executive change
  Brenda Cooperstone resigned as Director at Senti Biosciences, Inc..
  - Action: resigned
  - Role: Director
  source text: On September 23, 2026, Brenda Cooperstone, Ph.D., notified the Board of Directors (the "Board") of Senti Biosciences Holdings, Inc. (the "Company") of her decision to resign from the Board, effective immediately.
  evidence_url: https://www.sec.gov/Archives/edgar/data/1854270/000162828026063369/0001628280-26-063369-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.