---
schema_version: "secwatch.filing_event.v1"
accession: "0001628280-26-065291"
form_type: "8-K"
ticker: "SYRE"
cik: "0001636282"
company_name: "Spyre Therapeutics, Inc."
filed_at: "2026-10-07T12:00:25+00:00"
generated_at: "2026-10-12T16:01:38.093148+00:00"
event_type: "other_material"
sentiment: "neutral"
materiality_score: 0.55
calibrated_materiality_score: 0.55
confidence: "high"
source: SEC EDGAR
---

# Spyre Therapeutics prices $350M stock offering at $85.00/share to fund SPY072 Phase 3 push in hidradenitis suppurativa

## Summary
- Underwriting agreement dated October 5, 2026 with Jefferies, TD Securities, Leerink Partners and Stifel for 4,117,648 shares at $85.00/share, about $350.0M gross.
- Underwriters granted a 30-day option on up to 617,647 additional shares; offering expected to close on or about October 7, 2026.
- Proceeds fund Gastroenterology, Rheumatology and Dermatology programs, including preclinical studies, clinical trials, manufacturing and Phase 3 readiness.
- Part of the net proceeds will advance SPY072 into late-stage development for hidradenitis suppurativa, plus general infrastructure and potential in-licensing or acquisitions.
- Offering made under shelf registration statement on Form S-3 (File No. 333-297063) effective June 26, 2026; final prospectus supplement dated October 5, 2026.

## SEC filing metadata
- accession: 0001628280-26-065291
- form_type: 8-K
- ticker: SYRE
- cik: 0001636282
- company_name: Spyre Therapeutics, Inc.
- filed_at: 2026-10-07T12:00:25+00:00
- event_type: other_material
- sentiment: neutral
- materiality_score: 0.55
- calibrated_materiality_score: 0.55
- confidence: high
- sec_items: 1.01, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1636282/000162828026065291/0001628280-26-065291-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1636282/000162828026065291/syre-20261005.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001628280-26-065291
- JSON: https://secwatch.observer/filing/0001628280-26-065291.json
- Plain text: https://secwatch.observer/filing/0001628280-26-065291.txt

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.