8-K
filed February 27, 2025, 6:59 PM ET
ticker SYRE
CIK 0001636282
earnings
confidence high
sentiment positive
materiality 0.75
Spyre reports Q4 2024 net loss of $56.3M; cash $603M; pipeline on track with Phase 2 trials in 2025
Spyre Therapeutics, Inc.
- Cash, cash equivalents, and marketable securities $603.1M as of Dec 31, 2024; cash runway into H2 2028.
- Raised $230M in November 2024 public offering; Q4 net cash used in operations $37.2M.
- Interim Phase 1 data for SPY001 (α4β7) shows half-life >90 days supporting Q6M dosing; Phase 2 UC trial mid-2025.
- SPY002 (TL1A) Phase 1 interim data expected Q2 2025; Phase 2 RA trial initiation mid-2025; top-line 2026.
- SPY003 (IL-23) FIH trial starts Q1 2025 with interim data H2 2025; Phase 2 platform trial mid-2025.
Machine-readable event card
- schema_version
- secwatch.filing_event.v1
- accession
- 0001636282-25-000022
- form_type
- 8-K
- ticker
- SYRE
- cik
- 0001636282
- company_name
- Spyre Therapeutics, Inc.
- filed_at
- 2025-02-27T23:59:59+00:00
- discovered_at
- 2026-05-14T18:03:04.261845+00:00
- generated_at
- 2026-05-26T01:59:06.587611+00:00
- sec_items
- ["2.02", "9.01"]
- event_type
- earnings
- sentiment
- positive
- materiality_score
- 0.75
- calibrated_materiality_score
- 0.75
- confidence
- high
- secwatch_canonical_url
- https://secwatch.observer/filing/0001636282-25-000022
- json_url
- https://secwatch.observer/filing/0001636282-25-000022.json
- markdown_url
- https://secwatch.observer/filing/0001636282-25-000022.md
- text_url
- https://secwatch.observer/filing/0001636282-25-000022.txt
- edgar_index_url
- https://www.sec.gov/Archives/edgar/data/1636282/000163628225000022/0001636282-25-000022-index.htm
- edgar_primary_document_url
- https://www.sec.gov/Archives/edgar/data/1636282/000163628225000022/syre-20250227.htm
- generated_by_model
- deepseek-v4-flash:cloud@v2
- review_status
- machine_generated
- human_reviewed
- false
- corrected
- false
- correction_note
- null
- correction_timestamp
- null
- superseded_by
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