8-K
filed February 19, 2026, 6:59 PM ET
ticker SYRE
CIK 0001636282
earnings
confidence high
sentiment neutral
materiality 0.55
Spyre Therapeutics reports Q4 2025 net loss of $62.5M; cash $756.5M; Phase 2 readouts expected Q2/Q4 2026
Spyre Therapeutics, Inc.
- Q4 2025 net loss $62.5M (vs $56.3M Q4 2024); R&D expense $44.6M (vs $50.5M).
- Cash, cash equivalents, and marketable securities $756.5M at Dec 31, 2025; raised $316.2M gross in Oct 2025 public offering.
- On track for 6 proof-of-concept readouts in 2026: SKYLINE Part A (IBD) data expected Q2 2026; SKYWAY trial (RA, PsA, axSpA) data expected Q4 2026.
- Appointed Kate Tansey Chevlen as Chief Commercial Officer.
- Expected cash runway into second half of 2028.
Machine-readable event card
- schema_version
- secwatch.filing_event.v1
- accession
- 0001636282-26-000022
- form_type
- 8-K
- ticker
- SYRE
- cik
- 0001636282
- company_name
- Spyre Therapeutics, Inc.
- filed_at
- 2026-02-19T23:59:59+00:00
- discovered_at
- 2026-05-14T18:02:35.705329+00:00
- generated_at
- 2026-05-16T01:45:26.929446+00:00
- sec_items
- ["2.02", "9.01"]
- event_type
- earnings
- sentiment
- neutral
- materiality_score
- 0.55
- calibrated_materiality_score
- 0.55
- confidence
- high
- secwatch_canonical_url
- https://secwatch.observer/filing/0001636282-26-000022
- json_url
- https://secwatch.observer/filing/0001636282-26-000022.json
- markdown_url
- https://secwatch.observer/filing/0001636282-26-000022.md
- text_url
- https://secwatch.observer/filing/0001636282-26-000022.txt
- edgar_index_url
- https://www.sec.gov/Archives/edgar/data/1636282/000163628226000022/0001636282-26-000022-index.htm
- edgar_primary_document_url
- https://www.sec.gov/Archives/edgar/data/1636282/000163628226000022/syre-20260219.htm
- generated_by_model
- deepseek-v4-flash:cloud@v2
- review_status
- machine_generated
- human_reviewed
- false
- corrected
- false
- correction_note
- null
- correction_timestamp
- null
- superseded_by
- null
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