---
schema_version: "secwatch.filing_event.v1"
accession: "0001636282-26-000056"
form_type: "8-K"
ticker: "SYRE"
cik: "0001636282"
company_name: "Spyre Therapeutics, Inc."
filed_at: "2026-05-29T20:45:58+00:00"
generated_at: "2026-05-29T20:48:27.033144+00:00"
event_type: "other_material"
sentiment: "neutral"
materiality_score: 0.3
calibrated_materiality_score: 0.3
confidence: "high"
source: SEC EDGAR
---

# Spyre Therapeutics stockholders approve amended ESPP; director Peter Harwin resigns

## Summary
- Stockholders approved amended and restated 2016 ESPP (66.9M for, 45.5K against) at May 27 annual meeting.
- Director Peter Harwin resigned effective May 27, 2026; Board reduced from 8 to 7 directors.
- Elected Class I directors Mark McKenna, Cameron Turtle, and Laurie Stelzer to 2029 term.
- Non-binding advisory vote on executive compensation passed with 62.1M for, 4.8M against.
- Ratification of KPMG as independent auditor for FY2026 passed with 68.4M for, 670 against.

## SEC filing metadata
- accession: 0001636282-26-000056
- form_type: 8-K
- ticker: SYRE
- cik: 0001636282
- company_name: Spyre Therapeutics, Inc.
- filed_at: 2026-05-29T20:45:58+00:00
- event_type: other_material
- sentiment: neutral
- materiality_score: 0.3
- calibrated_materiality_score: 0.3
- confidence: high
- sec_items: 5.02, 5.07, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1636282/000163628226000056/0001636282-26-000056-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1636282/000163628226000056/syre-20260527.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001636282-26-000056
- JSON: https://secwatch.observer/filing/0001636282-26-000056.json
- Plain text: https://secwatch.observer/filing/0001636282-26-000056.txt

## Source-grounded claims
- claim_id: 70b0922a31
  claim: Peter Harwin resigned as Director at Spyre Therapeutics, Inc..
  evidence_excerpt: In addition, effective as of May 27, 2026, Peter Harwin resigned from the Board.
  evidence_url: https://www.sec.gov/Archives/edgar/data/1636282/000163628226000056/0001636282-26-000056-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.