{"schema_version":"secwatch.filing_event.v1","accession":"0001636282-26-000105","form_type":"8-K","ticker":"SYRE","cik":"0001636282","company_name":"Spyre Therapeutics, Inc.","filed_at":"2026-08-25T20:04:39+00:00","discovered_at":"2026-08-25T20:06:02.722562+00:00","generated_at":"2026-08-25T20:06:45.330773+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"negative","materiality_score":0.6,"calibrated_materiality_score":0.6,"confidence":"high","headline":"Spyre SPY072 RA sub-study shows significant efficacy vs placebo but misses bar for RA monotherapy","bullets":["SPY072 Low Dose ΔDAS28-CRP -1.9 (p<0.05) vs placebo -1.3 at Week 12; High Dose ACR20 63% (nominal p<0.05) vs placebo 43%.","Low Dose ACR50 38% (nominal p<0.05) vs placebo 19%; ACR70 4% vs 2%.","Adverse events 27% active vs 36% placebo; one serious TEAE per arm, none drug-related; one death in placebo arm.","Did not meet internal bar to prioritize SPY072 as monotherapy in RA; supports TL1A combo potential.","PsA/axSpA topline on track Q4 2026; SPY072 + IL-17A/F HS readout late 2027/early 2028."],"urls":{"canonical":"https://secwatch.observer/filing/0001636282-26-000105","json":"https://secwatch.observer/filing/0001636282-26-000105.json","markdown":"https://secwatch.observer/filing/0001636282-26-000105.md","text":"https://secwatch.observer/filing/0001636282-26-000105.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1636282/000163628226000105/0001636282-26-000105-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1636282/000163628226000105/syre-20260825.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-08-25T20:06:45.330773+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}