other material
confidence high
sentiment neutral
materiality 0.60
Novocure completes enrollment in Phase 3 TRIDENT trial for newly diagnosed glioblastoma; data expected 2026
NovoCure Ltd
- Final patient enrolled in global Phase 3 TRIDENT trial (950 patients) evaluating Optune Gio concurrent with radiation + temozolomide for newly diagnosed GBM.
- Patients randomized to TTFields + TMZ + radiation vs TMZ + radiation for 6 weeks, then all receive standard care (TTFields + maintenance TMZ).
- Primary endpoint is overall survival; secondary endpoints include PFS, safety, quality of life, and radiological response.
- Top-line data from the trial is anticipated in 2026; enrollment began in December 2020.