{"schema_version":"secwatch.filing_event.v1","accession":"0001650664-26-000049","form_type":"8-K","ticker":"EDIT","cik":"0001650664","company_name":"Editas Medicine, Inc.","filed_at":"2026-05-14T10:16:31+00:00","discovered_at":"2026-05-14T10:20:00.325866+00:00","generated_at":"2026-05-14T10:20:45.668865+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.7,"calibrated_materiality_score":0.7,"confidence":"high","headline":"Editas reports EDIT-401 achieves ≥90% LDL-C reduction in NHPs; durable through 6 months","bullets":["Single dose of EDIT-401 achieved ≥90% mean LDL-C reduction across all dose groups in non-human primates.","Reduction durable through ~6 months; achieved with 10-40% functional editing of LDLR alleles and ≥6-fold hepatic LDLR protein increase.","Promising preclinical safety profile: no adverse clinical observations at 1.5 mg/kg; undetectable oocyte delivery.","Data in Ldlr loss-of-function mice suggest dose adjustments may not be needed for HeFH patients.","Data support broader upregulation platform and continued advancement toward first-in-human clinical development."],"urls":{"canonical":"https://secwatch.observer/filing/0001650664-26-000049","json":"https://secwatch.observer/filing/0001650664-26-000049.json","markdown":"https://secwatch.observer/filing/0001650664-26-000049.md","text":"https://secwatch.observer/filing/0001650664-26-000049.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1650664/000165066426000049/0001650664-26-000049-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1650664/000165066426000049/edit-20260514.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-14T10:20:45.668865+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}