other material
confidence high
sentiment positive
materiality 0.90
CEL-SCI Phase 3 Multikine at ESMO: 45 responses, all in treatment group (1 in 100B chance), >3x OS benefit
CEL SCI CORP
- 45 RECIST neoadjuvant responses including 5 complete; all exclusive to Multikine groups (1 in 100 billion chance).
- Overall survival >3x longer for responders vs non-responders.
- Early tumor response (pre-surgery) noted only in Multikine groups, not control; prognostic and predictive for OS.
- Biomarker analysis: low tumor PDL1, high immune cell density, specific ratios predict Multikine efficacy.
- Data from the largest Phase 3 study ever in newly diagnosed locally advanced head and neck cancer.