other material
confidence high
sentiment positive
materiality 0.85
CEL-SCI's Multikine shows 28% absolute 5-year survival benefit in head & neck cancer target population at ESMO
CEL SCI CORP
- Target population: low PD-L1 (<10%), N0, no extracapsular spread; covers ~145,000 patients/year worldwide.
- 5-year survival 73% with Multikine vs 45% control (p=0.0015); hazard ratio 0.35, 65% risk reduction.
- Pre-surgery disease downstaging observed in 35% of Multikine patients; linked to improved survival.
- Pre-application regulatory filings submitted in UK and Europe; plans to file in US and Canada for immediate approval without confirmatory study.