{"schema_version":"secwatch.filing_event.v1","accession":"0001655759-25-000057","form_type":"8-K","ticker":"ARVN","cik":"0001655759","company_name":"ARVINAS, INC.","filed_at":"2025-03-11T23:59:59+00:00","discovered_at":"2026-05-14T18:03:04.330808+00:00","generated_at":"2026-05-24T23:46:05.151354+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.75,"calibrated_materiality_score":0.75,"confidence":"high","headline":"Arvinas and Pfizer report Phase 3 VERITAC-2 hit: vepdegestrant improves PFS in ESR1m breast cancer; ITT miss","bullets":["Vepdegestrant met primary endpoint in ESR1m population: statistically significant PFS improvement, exceeded target HR of 0.60.","ITT population did not achieve statistical significance for PFS.","Overall survival not mature (<25% of required events); trial continuing.","Safety profile consistent with prior studies; detailed results to be submitted to medical meeting and regulators.","First PROTAC degrader to show Phase 3 clinical benefit; Fast Track designation previously granted."],"urls":{"canonical":"https://secwatch.observer/filing/0001655759-25-000057","json":"https://secwatch.observer/filing/0001655759-25-000057.json","markdown":"https://secwatch.observer/filing/0001655759-25-000057.md","text":"https://secwatch.observer/filing/0001655759-25-000057.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1655759/000165575925000057/0001655759-25-000057-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1655759/000165575925000057/arvn-20250311.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-24T23:46:05.151354+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}