---
schema_version: "secwatch.filing_event.v1"
accession: "0001680367-23-000017"
form_type: "8-K"
ticker: "STTK"
cik: "0001680367"
company_name: "Shattuck Labs, Inc."
filed_at: "2023-02-23T23:59:59+00:00"
generated_at: "2026-06-19T02:51:51.751398+00:00"
event_type: "earnings"
sentiment: "negative"
materiality_score: 0.65
calibrated_materiality_score: 0.65
confidence: "high"
source: SEC EDGAR
---

# Shattuck Labs reports Q4 2022 net loss of $25.4M, discontinues SL-279252 program

## Summary
- Net loss Q4 2022 $25.4M ($0.60/share) vs net income $7.8M in Q4 2021; full-year net loss $101.9M.
- Cash and investments $161.3M at Dec 31, 2022, down from $268.8M; cash runway into H2 2024.
- Discontinued SL-279252 program after Phase 1 failed to meet 20% response rate threshold.
- Initiated Phase 1B trial of SL-172154 + mirvetuximab soravtansine in ovarian cancer; dosed first patients with azacitidine in AML/HR-MDS.
- Appointed Dr. George Fromm as CSO of ARC platform and Dr. Suresh de Silva as CSO of GADLEN platform.

## SEC filing metadata
- accession: 0001680367-23-000017
- form_type: 8-K
- ticker: STTK
- cik: 0001680367
- company_name: Shattuck Labs, Inc.
- filed_at: 2023-02-23T23:59:59+00:00
- event_type: earnings
- sentiment: negative
- materiality_score: 0.65
- calibrated_materiality_score: 0.65
- confidence: high
- sec_items: 2.02, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1680367/000168036723000017/0001680367-23-000017-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1680367/000168036723000017/sttk-20230223.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001680367-23-000017
- JSON: https://secwatch.observer/filing/0001680367-23-000017.json
- Plain text: https://secwatch.observer/filing/0001680367-23-000017.txt

## Key facts
- Earnings Releases
  Shattuck Labs, Inc. reported financial results for the three months and year ended December 31, 2022.
  - Period: the three months and year ended December 31, 2022
  - Result: reported results
  source text: On February 23, 2023, Shattuck Labs, Inc. issued a press release announcing its financial results for the three months and year ended December 31, 2022.
  evidence_url: https://www.sec.gov/Archives/edgar/data/1680367/000168036723000017/0001680367-23-000017-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.