---
schema_version: "secwatch.filing_event.v1"
accession: "0001683168-25-008287"
form_type: "8-K"
ticker: "VBIO"
cik: "0001787740"
company_name: "Valion Bio, Inc."
filed_at: "2025-11-13T23:59:59+00:00"
generated_at: "2026-05-16T20:29:42.295866+00:00"
event_type: "other_material"
sentiment: "positive"
materiality_score: 0.55
calibrated_materiality_score: 0.55
confidence: "high"
source: SEC EDGAR
---

# Tivic Health study: personalized ncVNS boosts HRV 46%, 8.9x vs fixed frequency

## Summary
- Personalizing stimulation frequency increased heart rate variability by 46%, 8.9x more effective than uniform frequency across subjects.
- Optimal frequency varied between visits for each subject, highlighting need for pre-treatment personalization.
- Electrode placement significantly impacted HRV; some configurations reduced HRV markedly while others increased it.
- Four minutes of ncVNS stimulation drove large HRV increase and was more effective than twenty minutes.
- CEO sees potential clinical utility in ischemic stroke, PTSD, and inflammatory diseases; plans in-house or partnered development.

## SEC filing metadata
- accession: 0001683168-25-008287
- form_type: 8-K
- ticker: VBIO
- cik: 0001787740
- company_name: Valion Bio, Inc.
- filed_at: 2025-11-13T23:59:59+00:00
- event_type: other_material
- sentiment: positive
- materiality_score: 0.55
- calibrated_materiality_score: 0.55
- confidence: high
- sec_items: 8.01, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1787740/000168316825008287/0001683168-25-008287-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1787740/000168316825008287/tivic_8k.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001683168-25-008287
- JSON: https://secwatch.observer/filing/0001683168-25-008287.json
- Plain text: https://secwatch.observer/filing/0001683168-25-008287.txt

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.