secwatch.observer — SEC 8-K summary
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Issuer:     Valion Bio, Inc. (VBIO)
CIK:        0001787740
Form:       8-K
Filed at:   2025-11-13T23:59:59+00:00
Accession:  0001683168-25-008287
Event type: other_material
Sentiment:  positive
Materiality: 0.55
Item codes: 8.01, 9.01
LLM model:  deepseek-v4-flash:cloud@v2

Tivic Health study: personalized ncVNS boosts HRV 46%, 8.9x vs fixed frequency
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- Personalizing stimulation frequency increased heart rate variability by 46%, 8.9x more effective than uniform frequency across subjects.
- Optimal frequency varied between visits for each subject, highlighting need for pre-treatment personalization.
- Electrode placement significantly impacted HRV; some configurations reduced HRV markedly while others increased it.
- Four minutes of ncVNS stimulation drove large HRV increase and was more effective than twenty minutes.
- CEO sees potential clinical utility in ischemic stroke, PTSD, and inflammatory diseases; plans in-house or partnered development.

Source:
  EDGAR index:    https://www.sec.gov/Archives/edgar/data/1787740/000168316825008287/0001683168-25-008287-index.htm
  Primary doc:    https://www.sec.gov/Archives/edgar/data/1787740/000168316825008287/tivic_8k.htm
  HTML page:      https://secwatch.observer/filing/0001683168-25-008287

License: Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer