Actuate Therapeutics receives FDA IND clearance for oral elraglusib Phase 1/2 study

ACTUATE THERAPEUTICS, INC.

• FDA cleared IND for Phase 1/2 study of oral elraglusib tablet in advanced solid tumors; initiation planned for 2H 2026.
• Oral formulation aims to achieve higher exposure than IV; PK exposure correlated with improved OS in mPDAC Phase 2.
• Elraglusib plus RAS inhibitor preclinical results expected mid-2026; combination potential in RAS-driven cancers.
• Industry veteran Martin Huber, MD, appointed to Board; former President and CEO of Mersana Therapeutics.

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