---
schema_version: "secwatch.filing_event.v1"
accession: "0001689375-26-000057"
form_type: "8-K"
ticker: "TRDA"
cik: "0001689375"
company_name: "Entrada Therapeutics, Inc."
filed_at: "2026-10-14T11:52:00+00:00"
generated_at: "2026-10-14T11:55:06.237012+00:00"
event_type: "other_material"
sentiment: "positive"
materiality_score: 0.65
calibrated_materiality_score: 0.65
confidence: "high"
source: SEC EDGAR
---

# Entrada's ENTR-601-45 shows safe 5 mg/kg profile, 0.10% dystrophin rise in DMD Cohort 1

## Summary
- Cohort 1 of Phase 1/2 ELEVATE-45-201 enrolled 8 ambulatory DMD patients (exon 45 skipping), randomized 3:1 to IV ENTR-601-45 5 mg/kg or placebo on days 1, 43 and 85.
- Dystrophin rose a mean 0.10% from baseline in treated patients (n=6, nominal p=0.03) vs a 0.02% mean decrease on placebo; exon skipping rose 0.15% (n=5) vs -0.04% on placebo.
- Favorable safety: headache most common TEAE (5 events in 2 participants); 1 participant had 2 serious TEAEs (vomiting, pyrexia) that resolved; no discontinuations; no hypomagnesemia or renal concerns.
- No functional benefit seen after three doses, as expected given patient age and baseline function; Q6W dosing equals about nine infusions a year vs 50+ for weekly regimens.
- Cohort 2 (10 mg/kg) enrollment complete and dosing ongoing, with data due H1 2027; Cohort 3 up to 15 mg/kg to follow, targeting higher exposure and dystrophin.

## SEC filing metadata
- accession: 0001689375-26-000057
- form_type: 8-K
- ticker: TRDA
- cik: 0001689375
- company_name: Entrada Therapeutics, Inc.
- filed_at: 2026-10-14T11:52:00+00:00
- event_type: other_material
- sentiment: positive
- materiality_score: 0.65
- calibrated_materiality_score: 0.65
- confidence: high
- sec_items: 7.01, 8.01, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1689375/000168937526000057/0001689375-26-000057-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1689375/000168937526000057/trda-20261014.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001689375-26-000057
- JSON: https://secwatch.observer/filing/0001689375-26-000057.json
- Plain text: https://secwatch.observer/filing/0001689375-26-000057.txt

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.