8-K
filed June 1, 2026, 4:28 PM ET
ticker PRAX
CIK 0001689548
other material
confidence high
sentiment negative
materiality 0.75
Praxis Precision Medicines: Phase 2/3 vormatrigine study fails primary endpoint in focal seizures
Praxis Precision Medicines, Inc.
- POWER1 study of vormatrigine in focal onset seizures did not meet primary success measure.
- Secondary 50% response rate achieved; higher 30 mg dose showed more pronounced seizure reduction in second half.
- Vormatrigine well-tolerated with <10% adverse event-related discontinuations; ~90% entered open-label extension.
- Company pausing enrollment in POWER2 study to reassess vormatrigine program and potential modifications.
Machine-readable event card
- schema_version
- secwatch.filing_event.v1
- accession
- 0001689548-26-000053
- form_type
- 8-K
- ticker
- PRAX
- cik
- 0001689548
- company_name
- Praxis Precision Medicines, Inc.
- filed_at
- 2026-06-01T20:28:49+00:00
- discovered_at
- 2026-06-01T20:30:00.264028+00:00
- generated_at
- 2026-06-01T20:37:46.199296+00:00
- sec_items
- ["8.01"]
- event_type
- other_material
- sentiment
- negative
- materiality_score
- 0.75
- calibrated_materiality_score
- 0.75
- confidence
- high
- secwatch_canonical_url
- https://secwatch.observer/filing/0001689548-26-000053
- json_url
- https://secwatch.observer/filing/0001689548-26-000053.json
- markdown_url
- https://secwatch.observer/filing/0001689548-26-000053.md
- text_url
- https://secwatch.observer/filing/0001689548-26-000053.txt
- edgar_index_url
- https://www.sec.gov/Archives/edgar/data/1689548/000168954826000053/0001689548-26-000053-index.htm
- edgar_primary_document_url
- https://www.sec.gov/Archives/edgar/data/1689548/000168954826000053/prax-20260601.htm
- generated_by_model
- deepseek-v4-flash:cloud@v2
- review_status
- machine_generated
- human_reviewed
- false
- corrected
- false
- correction_note
- null
- correction_timestamp
- null
- superseded_by
- null
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This headline and bullets were generated automatically by deepseek-v4-flash:cloud@v2 from the public filing. Read the source on SEC.gov before relying on any specific claim. Not investment advice.
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