{"schema_version":"secwatch.filing_event.v1","accession":"0001711279-23-000025","form_type":"8-K","ticker":"KRYS","cik":"0001711279","company_name":"Krystal Biotech, Inc.","filed_at":"2023-04-24T23:59:59+00:00","discovered_at":"2026-05-14T18:03:40.162064+00:00","generated_at":"2026-06-16T19:06:35.433416+00:00","sec_items":["7.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.55,"calibrated_materiality_score":0.55,"confidence":"high","headline":"Krystal Biotech reports positive ocular data from compassionate use of B-VEC in DEB patient","bullets":["Topical B-VEC achieved full corneal healing by 3 months and improved visual acuity from hand motion to 20/40 at 7 months.","No drug-related adverse events observed; treatment was well tolerated in the patient.","Patient had recurrent cicatrizing conjunctivitis; ocular complications affect >50% of recessive DEB patients.","Company plans to engage regulators to expand B-VEC utility for ocular DEB manifestations.","Ongoing preclinical studies evaluating intravitreal and subretinal deliveries for other ocular diseases."],"urls":{"canonical":"https://secwatch.observer/filing/0001711279-23-000025","json":"https://secwatch.observer/filing/0001711279-23-000025.json","markdown":"https://secwatch.observer/filing/0001711279-23-000025.md","text":"https://secwatch.observer/filing/0001711279-23-000025.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1711279/000171127923000025/0001711279-23-000025-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1711279/000171127923000025/krys-20230423.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-16T19:06:35.433416+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}