{"schema_version":"secwatch.filing_event.v1","accession":"0001711279-24-000023","form_type":"8-K","ticker":"KRYS","cik":"0001711279","company_name":"Krystal Biotech, Inc.","filed_at":"2024-05-08T23:59:59+00:00","discovered_at":"2026-05-14T18:03:19.694449+00:00","generated_at":"2026-06-02T11:41:14.759369+00:00","sec_items":["7.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.5,"calibrated_materiality_score":0.5,"confidence":"medium","headline":"Krystal Biotech presents preclinical ocular gene therapy data at ARVO 2024","bullets":["Subretinal and suprachoroidal injections achieved widespread mCherry expression across the retina in mice.","Vector transduced both photoreceptors (RHO+) and RPE cells (RPE65+) with minimal inflammation.","Intravitreal injection resulted in mCherry signal in cornea, iris, and ciliary body, not retina.","Low systemic dissemination detected; platform shows potential for inherited retinal diseases (IRDs)."],"urls":{"canonical":"https://secwatch.observer/filing/0001711279-24-000023","json":"https://secwatch.observer/filing/0001711279-24-000023.json","markdown":"https://secwatch.observer/filing/0001711279-24-000023.md","text":"https://secwatch.observer/filing/0001711279-24-000023.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1711279/000171127924000023/0001711279-24-000023-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1711279/000171127924000023/krys-20240507.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-02T11:41:14.759369+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}