{"schema_version":"secwatch.filing_event.v1","accession":"0001711279-25-000065","form_type":"8-K","ticker":"KRYS","cik":"0001711279","company_name":"Krystal Biotech, Inc.","filed_at":"2025-07-09T23:59:59+00:00","discovered_at":"2026-05-14T18:02:44.744569+00:00","generated_at":"2026-05-18T08:54:04.026862+00:00","sec_items":["7.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.65,"calibrated_materiality_score":0.65,"confidence":"high","headline":"Krystal Biotech doses first patient in Phase 1/2 trial of KB801 for neurotrophic keratitis","bullets":["First patient dosed in Phase 1/2 EMERALD-1 trial of KB801, a redosable eye-drop gene therapy for neurotrophic keratitis.","Study enrolls up to 27 adults with Stage 2 or 3 NK; 2:1 randomized to KB801 or placebo twice weekly for 8 weeks.","Primary endpoint: safety/tolerability; secondary: complete durable corneal healing at week 8.","NK diagnosed claims in US rose 115% from ~31,000 (2020) to ~68,000 (2024), per claims data.","Investor call/webcast July 9 at 8:30am ET to discuss KB801 program and trial design."],"urls":{"canonical":"https://secwatch.observer/filing/0001711279-25-000065","json":"https://secwatch.observer/filing/0001711279-25-000065.json","markdown":"https://secwatch.observer/filing/0001711279-25-000065.md","text":"https://secwatch.observer/filing/0001711279-25-000065.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1711279/000171127925000065/0001711279-25-000065-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1711279/000171127925000065/krys-20250709.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-18T08:54:04.026862+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}