earnings
confidence high
sentiment neutral
materiality 0.75
Denali Q2 net income $183M on Biogen opt-in; discontinues DNL919 in Alzheimer's
Denali Therapeutics Inc.
2023-Q2 EPS reported
$0.52
revenue$329,264,000
- Net income $183.4M (Q2 2022: net loss $58.8M) on $294.1M collaboration revenue from Biogen's ATV:Abeta option.
- Discontinued DNL919 (ATV:TREM2) in Alzheimer's due to narrow therapeutic window and evolving treatment landscape.
- Biogen exercised option to license ATV-amyloid-beta program; will handle development and commercialization.
- Revised BIIB122 (LRRK2) program: focus on LUMA study in Parkinson's; LIGHTHOUSE discontinued, no safety issues.
- Cash and marketable securities $1.19B; DNL310 showed ~40-64% NfL reduction in MPS II, IND cleared for DNL126.