{"schema_version":"secwatch.filing_event.v1","accession":"0001714899-24-000031","form_type":"8-K","ticker":"DNLI","cik":"0001714899","company_name":"Denali Therapeutics Inc.","filed_at":"2024-01-08T23:59:59+00:00","discovered_at":"2026-05-14T18:03:25.222480+00:00","generated_at":"2026-06-07T02:24:30.006925+00:00","sec_items":["7.01","9.01"],"event_type":"other_material","sentiment":"neutral","materiality_score":0.7,"calibrated_materiality_score":0.7,"confidence":"high","headline":"Denali Therapeutics outlines 2024 pipeline milestones, plans to spin out preclinical small molecule portfolio","bullets":["Cash of ~$1.12B as of Sep 30, 2023; expects 2024 OpEx ≤2023, extending runway into 2027.","Plans to complete enrollment in late-stage MPS II (COMPASS) and ALS (HEALEY) trials in 2024.","DNL593 (PTV:PGRN) Phase 1/2 paused for protocol modifications after infusion-related reactions in 2 participants.","Announces spin-out of preclinical small molecule portfolio into a separately funded NewCo.","IND-enabling studies for OTV:MAPT (Alzheimer's) and OTV:SNCA (Parkinson's) expected in 2024."],"urls":{"canonical":"https://secwatch.observer/filing/0001714899-24-000031","json":"https://secwatch.observer/filing/0001714899-24-000031.json","markdown":"https://secwatch.observer/filing/0001714899-24-000031.md","text":"https://secwatch.observer/filing/0001714899-24-000031.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1714899/000171489924000031/0001714899-24-000031-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1714899/000171489924000031/dnli-20240108.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-07T02:24:30.006925+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}