Arcus reports 46% confirmed ORR for casdatifan + cabozantinib in ccRCC post-immunotherapy

Arcus Biosciences, Inc.

Phase 1/1b ARC-20 interim analysis shows 46% cORR (11/24) per RECIST v1.1; median follow-up 5.3 months.
Response includes 1 complete response (4%) and 10 partial responses (42%); 50% had stable disease.
Safety evaluable population (n=42) showed acceptable safety profile with no new unexpected risks or overlapping toxicity.
Study evaluates casdatifan 100mg QD plus cabozantinib 60mg QD in patients with ccRCC who progressed on prior immunotherapy.

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