{"schema_version":"secwatch.filing_event.v1","accession":"0001724521-25-000120","form_type":"8-K","ticker":"RCUS","cik":"0001724521","company_name":"Arcus Biosciences, Inc.","filed_at":"2025-12-12T23:59:59+00:00","discovered_at":"2026-05-14T18:02:40.257732+00:00","generated_at":"2026-05-16T13:22:16.612237+00:00","sec_items":["8.01"],"event_type":"other_material","sentiment":"negative","materiality_score":0.75,"calibrated_materiality_score":0.75,"confidence":"high","headline":"Arcus ends Phase 3 STAR-221 domvanalimab study on futility; no OS benefit","bullets":["Phase 3 STAR-221 of domvanalimab + zimberelimab + chemo vs nivolumab + chemo stopped for futility after IDMC review.","Domvanalimab combo did not improve overall survival vs nivolumab + chemo; safety profile similar.","Phase 2 EDGE-Gastric also discontinued; company and Gilead communicating with investigators.","R&D focus shifts to HIF-2a inhibitor casdatifan and small molecule inflammation programs; MRGPRX2 inhibitor clinical entry expected 2026.","Cash runway expected to fund operations until at least second half 2028."],"urls":{"canonical":"https://secwatch.observer/filing/0001724521-25-000120","json":"https://secwatch.observer/filing/0001724521-25-000120.json","markdown":"https://secwatch.observer/filing/0001724521-25-000120.md","text":"https://secwatch.observer/filing/0001724521-25-000120.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1724521/000172452125000120/0001724521-25-000120-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1724521/000172452125000120/rcus-20251212.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-16T13:22:16.612237+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}