{"schema_version":"secwatch.filing_event.v1","accession":"0001725160-23-000129","form_type":"8-K","ticker":"ZNTL","cik":"0001725160","company_name":"Zentalis Pharmaceuticals, Inc.","filed_at":"2023-06-05T23:59:59+00:00","discovered_at":"2026-05-14T18:03:40.250725+00:00","generated_at":"2026-06-14T07:27:33.967055+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"neutral","materiality_score":0.65,"calibrated_materiality_score":0.65,"confidence":"high","headline":"Zentalis presents ASCO data: azenosertib+chemo response linked to Cyclin E1","bullets":["Azenosertib + chemo (paclitaxel, carboplatin, gemcitabine, PLD) shows ORR of 34% across 94 evaluable patients.","Cyclin E1 IHC+ patients had median PFS 9.86 mo vs 3.25 mo for low (HR 0.37, p=0.0078).","RP2D set: azenosertib 300 mg QD 5:2 + paclitaxel 80 mg/m2; RP2D with carboplatin 200 mg QD 5:2.","Phase 3 design proposed comparing azenosertib+chemo vs carboplatin doublet in Cyclin E1+ platinum-sensitive ovarian cancer.","ZN-d5 (BCL-2) + azenosertib phase 1/2 in AML enrolling; no efficacy data yet."],"urls":{"canonical":"https://secwatch.observer/filing/0001725160-23-000129","json":"https://secwatch.observer/filing/0001725160-23-000129.json","markdown":"https://secwatch.observer/filing/0001725160-23-000129.md","text":"https://secwatch.observer/filing/0001725160-23-000129.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1725160/000172516023000129/0001725160-23-000129-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1725160/000172516023000129/zntl-20230605.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-14T07:27:33.967055+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}