{"schema_version":"secwatch.filing_event.v1","accession":"0001725160-24-000157","form_type":"8-K","ticker":"ZNTL","cik":"0001725160","company_name":"Zentalis Pharmaceuticals, Inc.","filed_at":"2024-08-09T23:59:59+00:00","discovered_at":"2026-05-14T18:03:14.285556+00:00","generated_at":"2026-05-31T10:26:36.273493+00:00","sec_items":["2.02","9.01"],"event_type":"earnings","sentiment":"negative","materiality_score":0.8,"calibrated_materiality_score":0.8,"confidence":"high","headline":"Zentalis Q2 cash $426.4M; FDA partial hold on azenosertib; CMO resigns","bullets":["Cash, equivalents and marketable securities $426.4M as of June 30; R&D expense $48.4M (Q2 2024); cash runway into mid-2026.","FDA placed partial clinical hold on azenosertib June 18 after two deaths in DENALI study; resolution timelines uncertain.","Discontinued development of BCL-2 inhibitor ZN-d5; combination with azenosertib in AML phase 1 stopped.","CMO Diana Hausman stepped down effective Aug 8; CEO Kimberly Blackwell appointed Interim CMO; replacement search ongoing.","Expected 2H milestones: DENALI Cohort 1b topline, azenosertib Phase 1b final results, MAMMOTH data with GSK, others."],"urls":{"canonical":"https://secwatch.observer/filing/0001725160-24-000157","json":"https://secwatch.observer/filing/0001725160-24-000157.json","markdown":"https://secwatch.observer/filing/0001725160-24-000157.md","text":"https://secwatch.observer/filing/0001725160-24-000157.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1725160/000172516024000157/0001725160-24-000157-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1725160/000172516024000157/zntl-20240809.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-31T10:26:36.273493+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}