{"schema_version":"secwatch.filing_event.v1","accession":"0001736730-25-000041","form_type":"8-K","ticker":"CAMP","cik":"0001736730","company_name":"Camp4 Therapeutics Corp","filed_at":"2025-05-16T23:59:59+00:00","discovered_at":"2026-05-14T18:02:49.517133+00:00","generated_at":"2026-05-21T03:25:13.108479+00:00","sec_items":["7.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.6,"calibrated_materiality_score":0.6,"confidence":"high","headline":"CAMP4 reports SYNGAP1 protein increase in NHPs and favorable Phase 1 safety data for UCD program at ASGCT","bullets":["CMP-SYNGAP-01 restored SYNGAP1 protein to near-normal in haploinsufficient mice and rescued motor/learning defects.","In NHPs, biweekly intrathecal CMP-SYNGAP-01 achieved ~1.5-fold SYNGAP1 increase in relevant brain regions.","Phase 1 SAD data for CMP-CPS-001 in 48 healthy volunteers: well tolerated, no serious AEs, dose-dependent PK.","UCD preclinical: CMP-CPS-001 increased ureagenesis up to 40% in NHPs and reduced ammonia in mice.","Company plans to expand Phase 1 into OTC heterozygotes with reduced urea cycle function."],"urls":{"canonical":"https://secwatch.observer/filing/0001736730-25-000041","json":"https://secwatch.observer/filing/0001736730-25-000041.json","markdown":"https://secwatch.observer/filing/0001736730-25-000041.md","text":"https://secwatch.observer/filing/0001736730-25-000041.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1736730/000173673025000041/0001736730-25-000041-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1736730/000173673025000041/camp-20250516.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-21T03:25:13.108479+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}