{"schema_version":"secwatch.filing_event.v1","accession":"0001737287-22-000074","form_type":"8-K","ticker":"ALLO","cik":"0001737287","company_name":"Allogene Therapeutics, Inc.","filed_at":"2022-10-06T23:59:59+00:00","discovered_at":"2026-05-14T18:03:51.927838+00:00","generated_at":"2026-06-23T05:06:21.287658+00:00","sec_items":["8.01"],"event_type":"other_material","sentiment":"neutral","materiality_score":0.6,"calibrated_materiality_score":0.6,"confidence":"high","headline":"Allogene initiates Phase 2 ALPHA2 trial of ALLO-501A in r/r LBCL; plans EXPAND trial for ALLO-647","bullets":["ALPHA2 trial will enroll ~100 r/r LBCL patients with single 120M CAR+ cell dose; primary endpoint ORR.","EXPAND trial (~70 patients) randomized to assess ALLO-647 contribution to lymphodepletion regimen.","FDA cleared manufacturing from CF1 using non-Alloy process; Alloy process being implemented at CF1.","Company plans to seek FDA approval based on ALPHA2 and EXPAND trials assuming favorable outcomes.","CD19 program update, including longer-term Phase 1 follow-up with Alloy process, expected end of 2022."],"urls":{"canonical":"https://secwatch.observer/filing/0001737287-22-000074","json":"https://secwatch.observer/filing/0001737287-22-000074.json","markdown":"https://secwatch.observer/filing/0001737287-22-000074.md","text":"https://secwatch.observer/filing/0001737287-22-000074.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1737287/000173728722000074/0001737287-22-000074-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1737287/000173728722000074/allo-20221006.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-23T05:06:21.287658+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}