---
schema_version: "secwatch.filing_event.v1"
accession: "0001808805-23-000005"
form_type: "8-K"
ticker: "NAUT"
cik: "0001808805"
company_name: "Nautilus Biotechnology, Inc."
filed_at: "2023-02-23T23:59:59+00:00"
generated_at: "2026-06-19T03:12:49.514060+00:00"
event_type: "earnings"
sentiment: "neutral"
materiality_score: 0.55
calibrated_materiality_score: 0.55
confidence: "high"
source: SEC EDGAR
---

# Nautilus Biotechnology reports FY2022 net loss of $57.9M; cash runway into 2025

## Summary
- Net loss $57.9M for FY2022 vs $50.3M in FY2021; operating expenses $63.6M, up 26%.
- Cash, cash equivalents, and investments $313.6M as of Dec 31, 2022; runway into 2025.
- Strategic partnership with TGen to study Nautilus platform for DIPG childhood cancer.
- Opened San Diego office in University Town Center to expand geographic footprint.
- Q4 2022 expenses below peak Q4 2021 levels, helping preserve cash.

## SEC filing metadata
- accession: 0001808805-23-000005
- form_type: 8-K
- ticker: NAUT
- cik: 0001808805
- company_name: Nautilus Biotechnology, Inc.
- filed_at: 2023-02-23T23:59:59+00:00
- event_type: earnings
- sentiment: neutral
- materiality_score: 0.55
- calibrated_materiality_score: 0.55
- confidence: high
- sec_items: 2.02, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1808805/000180880523000005/0001808805-23-000005-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1808805/000180880523000005/naut-20230223.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001808805-23-000005
- JSON: https://secwatch.observer/filing/0001808805-23-000005.json
- Plain text: https://secwatch.observer/filing/0001808805-23-000005.txt

## Key facts
- Earnings Releases
  Nautilus Biotechnology, Inc. reported the year-ended December 31, 2022 results: net income $57.9 million.
  - Period: the year-ended December 31, 2022
  - Net income: $57.9 million
  - Result: reported results
  source text: Net loss was $57.9 million for the year-ended December 31, 2022
  evidence_url: https://www.sec.gov/Archives/edgar/data/1808805/000180880523000005/0001808805-23-000005-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.