{"schema_version":"secwatch.filing_event.v1","accession":"0001835268-25-000029","form_type":"8-K","ticker":"CNTB","cik":"0001835268","company_name":"Connect Biopharma Holdings Ltd","filed_at":"2025-05-14T23:59:59+00:00","discovered_at":"2026-05-14T18:02:50.032701+00:00","generated_at":"2026-05-21T09:57:57.733508+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"neutral","materiality_score":0.6,"calibrated_materiality_score":0.6,"confidence":"high","headline":"Connect Biopharma starts Phase 2 COPD study of rademikibart, topline data expected 1H 2026","bullets":["Phase 2 Seabreeze STAT COPD study initiated after FDA agreement on final protocol.","Study evaluates single-dose rademikibart vs placebo as adjunct to standard of care for acute COPD exacerbations.","Approximately 160 participants with type 2 inflammation (eosinophils ≥300 cells/μL) will be enrolled.","Primary endpoint: treatment failure rate over 28 days; topline data expected in first half of 2026.","Post-hoc analysis of prior Phase 2b asthma data in COPD-like patients to be presented at ATS 2025."],"urls":{"canonical":"https://secwatch.observer/filing/0001835268-25-000029","json":"https://secwatch.observer/filing/0001835268-25-000029.json","markdown":"https://secwatch.observer/filing/0001835268-25-000029.md","text":"https://secwatch.observer/filing/0001835268-25-000029.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1835268/000183526825000029/0001835268-25-000029-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1835268/000183526825000029/cntb-20250514.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-21T09:57:57.733508+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}