{"schema_version":"secwatch.filing_event.v1","accession":"0001835268-26-000034","form_type":"8-K","ticker":"CNTB","cik":"0001835268","company_name":"Connect Biopharma Holdings Ltd","filed_at":"2026-09-15T11:06:34+00:00","discovered_at":"2026-09-15T11:10:01.017759+00:00","generated_at":"2026-09-15T11:10:17.718543+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.75,"calibrated_materiality_score":0.75,"confidence":"high","headline":"Rademikibart Phase 2 asthma: FEV1 up 130mL (p=0.023); treatment failure down 66% (p=0.153)","bullets":["FEV1 at Day 7 improved 250 mL vs 120 mL placebo (130 mL delta, p=0.023), a statistically significant key secondary.","Treatment failure within 28 days reduced ~66% vs placebo but missed significance (p=0.153) due to lower-than-expected event rate.","ED/unscheduled visits for worsening asthma cut 50% vs placebo; safety comparable, 1 SAE rademikibart vs 3 placebo.","160 patients (79 rademikibart 600mg, 81 placebo); FDA Phase 3 alignment planned; COPD (CBP-201-207) data due later this month."],"urls":{"canonical":"https://secwatch.observer/filing/0001835268-26-000034","json":"https://secwatch.observer/filing/0001835268-26-000034.json","markdown":"https://secwatch.observer/filing/0001835268-26-000034.md","text":"https://secwatch.observer/filing/0001835268-26-000034.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1835268/000183526826000034/0001835268-26-000034-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1835268/000183526826000034/cntb-20260915.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-09-15T11:10:17.718543+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}