FDA clears IND for Centessa's ORX142, Phase 1 study in sleep-deprived volunteers planned

Centessa Pharmaceuticals plc

FDA cleared IND for ORX142, a novel OX2R agonist for neurological/neurodegenerative disorders.
Phase 1 study will evaluate safety, PK, and PD (MWT, KSS) in acutely sleep-deprived healthy adults.
Clinical data from Phase 1 expected this year; study initiation imminent.
ORX142 is second orexin franchise candidate; ORX750 in Phase 2a for narcolepsy/IH.

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