{"schema_version":"secwatch.filing_event.v1","accession":"0001847903-25-000154","form_type":"8-K","ticker":"CNTA","cik":"0001847903","company_name":"Centessa Pharmaceuticals plc","filed_at":"2025-11-05T23:59:59+00:00","discovered_at":"2026-05-14T18:02:40.790642+00:00","generated_at":"2026-05-17T00:24:23.045673+00:00","sec_items":["2.02","7.01","9.01"],"event_type":"earnings","sentiment":"positive","materiality_score":0.8,"calibrated_materiality_score":0.8,"confidence":"high","headline":"Centessa reports Q3 net loss of $54.9M; ORX750 Phase 2a meets endpoints in NT1, NT2, IH","bullets":["Net loss of $54.9M in Q3 2025 vs $42.6M in Q3 2024; R&D expenses rose to $41.6M.","Cash and investments $349M as of Sep 30, 2025, expected to fund operations into mid-2027.","ORX750 Phase 2a showed statistically significant improvements on MWT, ESS, and cataplexy rate across NT1, NT2, and IH at low doses.","ORX142 Phase 1 demonstrated rapid onset and differentiated PK; patient studies planned for Q1 2026.","Registrational program for ORX750 expected to start Q1 2026; ORX489 IND-enabling studies ongoing."],"urls":{"canonical":"https://secwatch.observer/filing/0001847903-25-000154","json":"https://secwatch.observer/filing/0001847903-25-000154.json","markdown":"https://secwatch.observer/filing/0001847903-25-000154.md","text":"https://secwatch.observer/filing/0001847903-25-000154.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1847903/000184790325000154/0001847903-25-000154-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1847903/000184790325000154/cnta-20251105.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-17T00:24:23.045673+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}