{"schema_version":"secwatch.filing_event.v1","accession":"0001933414-23-000081","form_type":"8-K","ticker":"MLYS","cik":"0001933414","company_name":"Mineralys Therapeutics, Inc.","filed_at":"2023-11-02T23:59:59+00:00","discovered_at":"2026-05-14T18:03:31.419182+00:00","generated_at":"2026-06-09T01:09:50.462733+00:00","sec_items":["7.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.65,"calibrated_materiality_score":0.65,"confidence":"high","headline":"Mineralys presents post-hoc analysis linking BMI to enhanced BP reduction with lorundrostat","bullets":["Post-hoc analysis from Target-HTN Phase 2 trial: median systolic BP reduction of 32 mmHg in responder population.","Enhanced response proportional to BMI; modeled reduction ~12 mmHg at BMI 30 and ~19 mmHg at BMI 40 kg/m².","Statistically significant linear regression association between BMI and systolic BP reduction (BMI 22.5-40 kg/m²).","Advance-HTN pivotal trial enrolling; Phase 3 Launch-HTN trial expected to start before end of 2023.","Data supports obesity-associated aldosterone-dependent hypertensive endotype as predictor of response."],"urls":{"canonical":"https://secwatch.observer/filing/0001933414-23-000081","json":"https://secwatch.observer/filing/0001933414-23-000081.json","markdown":"https://secwatch.observer/filing/0001933414-23-000081.md","text":"https://secwatch.observer/filing/0001933414-23-000081.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1933414/000193341423000081/0001933414-23-000081-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1933414/000193341423000081/mlys-20231102.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-09T01:09:50.462733+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}