---
schema_version: "secwatch.filing_event.v1"
accession: "0001937653-23-000026"
form_type: "8-K"
ticker: "ZYME"
cik: "0001937653"
company_name: "Zymeworks Inc."
filed_at: "2023-08-10T23:59:59+00:00"
generated_at: "2026-06-11T19:37:11.562913+00:00"
event_type: "earnings"
sentiment: "positive"
materiality_score: 0.7
calibrated_materiality_score: 0.7
confidence: "high"
source: SEC EDGAR
---

# Zymeworks Q2 2023 net loss narrows 45% to $75.5M; zanidatamab Phase 2b data show 41.3% ORR

## Summary
- Revenue surged to $42.6M (from $7.4M) on Jazz collaboration; net loss improved 45% YoY to $75.5M.
- Cash and marketable securities $431.4M; runway expected through at least end-2026.
- Zanidatamab Phase 2b BTC results: cORR 41.3%, median DOR 12.9 months, median PFS 5.5 months.
- Next IND candidate ZW220 (NaPi2b-TOPO1i ADC) targeting NSCLC/ovarian cancer; IND filing expected 1H 2025.
- Appointed Carlos E. Campoy to board; reiterated 2023 non-GAAP cash burn guidance $110M-$130M.

## SEC filing metadata
- accession: 0001937653-23-000026
- form_type: 8-K
- ticker: ZYME
- cik: 0001937653
- company_name: Zymeworks Inc.
- filed_at: 2023-08-10T23:59:59+00:00
- event_type: earnings
- sentiment: positive
- materiality_score: 0.7
- calibrated_materiality_score: 0.7
- confidence: high
- sec_items: 2.02, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1937653/000193765323000026/0001937653-23-000026-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1937653/000193765323000026/zyme-20230810.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001937653-23-000026
- JSON: https://secwatch.observer/filing/0001937653-23-000026.json
- Plain text: https://secwatch.observer/filing/0001937653-23-000026.txt

## Key facts
- Earnings Releases
  Zymeworks Inc. reported financial results for three and six months ended June 30, 2023.
  - Period: three and six months ended June 30, 2023
  - Result: reported results
  source text: On August 10, 2023 , Zymeworks Inc. (the “Company”) issued a press release announcing its financial results for the fiscal quarter ended June 30, 2023.
  evidence_url: https://www.sec.gov/Archives/edgar/data/1937653/000193765323000026/0001937653-23-000026-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.