Upstream Bio Phase 2 VIBRANT trial meets primary endpoint for verekitug in CRSwNP

Upstream Bio, Inc.

Placebo-adjusted reduction in nasal polyp score of -1.8 (p<0.0001) at Week 24; key secondary endpoint nasal congestion score reduced -0.8 (p=0.0003).
76% reduction in need for surgery or systemic corticosteroids (p=0.03); no serious adverse events observed.
Verekitug (100 mg every 12 weeks) generally well tolerated; company plans to engage regulators and present at upcoming medical conference.
Additional top-line data for verekitug in severe asthma expected in coming months.

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