other material
confidence high
sentiment negative
materiality 0.75
PepGen voluntarily pauses Phase 2 CONNECT2-EDO51 study; awaits 10 mg/kg data from CONNECT1
PepGen Inc.
- Temporarily pauses CONNECT2-EDO51 in DMD until review of 10 mg/kg data from ongoing CONNECT1-EDO51 study.
- No new safety issues observed in PGN-EDO51 program since safety update on January 23, 2025.
- CONNECT1 10 mg/kg cohort fully enrolled; data expected in third quarter of 2025.
- Resources focused on completing CONNECT1 and advancing FREEDOM-DM1 studies in myotonic dystrophy type 1.
- CEO states pause allows gathering additional safety data and potential improvement of CONNECT2 design.