Annovis Bio: buntanetap + GLP-1 agonist shows synergistic cognitive boost in AD mouse model

Annovis Bio, Inc.

Combination of buntanetap and dulaglutide (Trulicity) restored cognitive function beyond healthy controls in Alzheimer's mouse model.
Buntanetap alone restored to 100%, dulaglutide alone to 80%; combination showed 6-10x increase in efficacy.
GLP-1 agonist dulaglutide was chosen for its good blood-brain barrier permeability among single-chain peptides.
CEO Maria Maccecchini noted synergy could enhance treatment outcomes while minimizing side effects.

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