IO Biotech shareholders elect directors and approve officer exculpation amendment at annual meeting

Proposal Three: Ratification of Appointment of Independent Registered Public Accounting Firm The stockholders ratified the appointment of EY Godkendt Revisionspartnerselskab as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2023 by the following vote: For Against Abstain Broker Non-Votes 20,815,596 111,302 4,683 —

Proposal One: Election of Class II Directors Each of Priyanka Belawat and Christian Elling was elected to serve as a class II director to hold office until the Company’s 2026 Annual Meeting of Stockholders and until the election and qualification of his or her successor. Votes were cast as follows: For Withheld Broker Non-Votes Priyanka Belawat, Ph.D. 18,148,150 1,993,756 789,675 Christian Elling, Ph.D. 18,139,833 2,002,073 789,675

Proposal Two: Amendment to the Certificate of Incorporation to Provide Exculpation for Officers The stockholders approved an amendment to the Company’s Certificate of Incorporation to provide exculpation for officers by the following vote: For Against Abstain Broker Non-Votes 20,021,960 115,161 4,875 789,675