Spero Therapeutics, Inc. (SPRO): restructuring charge — Spero suspends SPR720 development after Phase 2a miss; cuts workforce 39%, extends cash runway to mid-2026

Spero Therapeutics, Inc.

SPR720 Phase 2a interim analysis did not meet primary endpoint; 3 cases of reversible grade 3 hepatotoxicity at 1,000 mg dose.
Company restructuring with ~39% workforce reduction; expects ~$1.1M in cash restructuring charges.
Unaudited Q3 2024 cash ~$76.3M; cash runway extended into mid-2026.
Tebipenem HBr PIVOT-PO Phase 3 trial on track for enrollment completion in 2H 2025.
IND cleared for SPR206 Phase 2 trial in HABP/VABP, contingent on non-dilutive funding.

item 2.02 item 2.05 item 7.01 item 8.01 item 9.01

Key facts

Extracted from this filing and checked against the source text.

Restructurings & Charges SEC 8-K Item 2.05/2.06 confidence 0.9

Spero Therapeutics, Inc. announced a restructuring with charges of approximately $1.1 million affecting Company-wide (approximately 39%).

Type: restructuring
Charge: approximately $1.1 million
Affected area: Company-wide
Headcount: approximately 39%

Exact text from the filing

The Company estimates that it will incur aggregate restructuring charges of approximately $1.1 million in cash expenditures in connection with the reduction in workforce related to severance pay and other related termination benefits.

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Spero Therapeutics, Inc. filing history →

Source: SEC EDGAR

accession 0001193125-24-246627

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