other material
confidence high
sentiment positive
materiality 0.75
TSC-101 Cohort C: 11/14 patients achieved complete donor chimerism; Phase 3 start planned this month
TScan Therapeutics, Inc.
- 11 of 14 patients achieved complete donor chimerism within ~3 weeks of first TSC-101 infusion; 2 additional patients approaching.
- ~90% manufacturing success rate (17/19) with commercial-ready process; 14/19 patients received first infusion.
- One TP53-mutated AML patient remained in complete donor chimerism 6 months post-HCT.
- TSC-101 well-tolerated; safety consistent with Cohort A; company plans to initiate Phase 3 ALLOHA-2 study this month.