Highest-materiality recent filing
TScan Therapeutics signs separation agreements with CFO Amello and CMO Louis
CFO Jason A. Amello and CMO Chrystal Louis, M.D., MPH, will terminate employment on the earlier of Nov. 1, 2026 or the start of other employment.
TScan Therapeutics approves retention program with cash and RSUs for CEO and Chief Legal Officer
CEO Gavin MacBeath receives $822,000 cash award and 2,400,000 RSUs under Retention Program.
TScan cuts 75% of workforce, pauses Phase 3 ALLOHA-2, refocuses on in vivo solid tumors
Workforce reduction ~75%; ~$4.1M employee-related costs; $55.0M cumulative savings through 2027; cash runway into Q4 2027.
Amgen terminates Crohn's disease collaboration with TScan; effective Nov 10, 2026
Amgen gave notice Aug 12, 2026 to terminate Research Collaboration and License Agreement; effective Nov 10, 2026.
TScan Q2 net loss narrows to $30.4M; first patient dosed in Phase 3 ALLOHA-2 trial
Q2 2026 net loss $30.4M vs $37.0M; revenue $1.1M vs $3.1M, down on Amgen collaboration timing.
TSC-101 Cohort C: 11/14 patients achieved complete donor chimerism; Phase 3 start planned this month
11 of 14 patients achieved complete donor chimerism within ~3 weeks of first TSC-101 infusion; 2 additional patients approaching.
TScan Therapeutics stockholders approve doubling authorized shares to 600M and elect directors
Katina Dorton (19.7M for) and R. Keith Woods (23.3M for) elected as Class II directors for three-year terms.
TScan Q1 2026 revenue $1.0M, net loss $28.7M, cash funds into H2 2027
Revenue $1.0M vs $2.2M Q1 2025; net loss $28.7M vs $34.1M; R&D expenses $21.9M down from $29.8M.
TScan Therapeutics VP of Finance resigns; CFO Amello named principal accounting officer
Leiden Dworak resigns as VP of Finance and principal accounting officer, effective April 10, 2026.
Net loss $23.0M in Q4 2025 vs $35.8M Q4 2024; revenue $2.6M vs $0.7M.
TScan furnishes corporate presentation at J.P. Morgan conference; no specific new data disclosed
Furnished corporate presentation in connection with 44th Annual J.P. Morgan Healthcare Conference.
TScan Therapeutics retention program grants cash and RSUs to CEO, CFO, CMO tied to TSC-101 milestone
Board approved retention program for CEO Gavin MacBeath, CFO Jason Amello, and CMO Chrystal Louis.
TScan Q3 net loss $35.7M; pauses solid tumor enrollment, advances heme pivotal trial
Revenue $2.5M (up from $1.0M YoY); net loss $35.7M vs $29.9M; cash $184.5M funds into H2 2027.
FDA agrees to pivotal study design for TSC-101 in AML/MDS; trial to start Q2 2026.
TScan Therapeutics updates corporate presentation with adjusted timelines and pipeline updates
Company furnished updated corporate presentation on September 9, 2025 for investor meetings.
TScan Therapeutics appoints Leiden Dworak as Principal Accounting Officer
Appointment effective August 14, 2025; Dworak also serves as VP Finance since April 2022.
TScan Q2 net loss $37M, cash ~$218M funds ops into Q1 2027; heme/solid tumor milestones on track
Q2 2025 revenue $3.1M (vs $0.5M YoY) from Amgen collaboration; R&D spend $32.6M.
TScan Therapeutics holds annual meeting; elects three Class I directors and ratifies auditor
Elected Stephen Biggar, Gavin MacBeath, and Garry Nicholson as Class I directors for three-year terms through 2028.
TScan Q1 net loss $34.1M; cash runway into Q1 2027; registrational trial H2 2025
Revenue $2.2M (up from $0.6M YoY); R&D expense $29.8M; net loss $34.1M vs $30.1M YoY.
TScan Q4 net loss $35.8M; revenue down 90% YoY; heme relapse data positive
Net loss $35.8M in Q4 vs $19.6M YoY; full-year net loss $127.5M vs $89.2M.
Entered securities purchase agreement for pre-funded warrants to purchase 7.5M shares at $4.00 per warrant, gross proceeds ~$30M.
TScan refinances convertible debt with up to $52.5M term loan from Silicon Valley Bank
First tranche of $32.5M drawn at closing; used to retire $17.2M existing convertible debt with K2 HealthVentures plus $2.1M exit fee.
TScan reports positive Phase 1 ALLOHA data; plans registrational trial for TSC-101 in H2 2025
Event-free survival strongly favored treatment arm (HR=0.30, p=0.04); relapse probability trended lower (HR=0.28, p=0.14).
TScan converts $15M loan principal into 3.13M shares at $4.785
K2 HealthVentures converted $15M of convertible term loan into 3,134,796 voting common shares at $4.785/share.
TScan Q3 net loss $29.9M; ALLOHA heme trial shows no relapses in 16 treatment patients
Net loss $29.9M in Q3 2024 vs $23.0M in Q3 2023; revenue $1.0M vs $3.9M.
TScan Therapeutics expands leased space by ~25,628 sq ft at Waltham HQ through 2029
Lease amendment adds 25,628 rentable sq ft to existing 25,472 sq ft at 830 Winter St, Waltham, MA.
TScan Q2 net loss $31.7M; revenue falls to $0.5M; RMAT designation for lead candidates
Revenue $0.5M, down from $3.1M in Q2 2023, primarily due to Amgen collaboration timing.
TScan Therapeutics appoints Garry Nicholson to board, Stephen Biggar named chair; Barberich retires
Timothy Barberich resigned as director and Chair effective June 12, 2024; no disagreement cited.
Net loss of $30.1M for Q1 2024 compared to $22.6M in Q1 2023; revenue fell to $0.6M from $6.8M.
TScan Therapeutics prices upsized $150M public offering; provides preliminary cash of $162.8M
Pricing of 2,472,581 shares at $7.13/share and pre-funded warrants for 18,577,419 shares at $7.1299/warrant.
TScan Therapeutics: all 8 heme patients relapse-free >10 months; solid tumor 60% qualify
All 8 TSC-100/101 treated patients remain MRD-negative and relapse-free (median follow-up >10 months); no dose-limiting toxicities.
TScan Therapeutics appoints Chrystal U. Louis as CMO; Dr. Debora Barton departs
Chrystal U. Louis, M.D., M.P.H., named Chief Medical Officer effective April 8, 2024.
TScan Q4 net loss $19.6M; all 8 TSC-100/101 patients relapse-free
Q4 revenue $7.2M (up from $3.1M YoY); full-year revenue $21.0M. R&D expenses $22.4M Q4, $88.2M full year.
TScan Therapeutics appoints Jason A. Amello as CFO effective Jan 29, 2024
Jason A. Amello appointed CFO effective January 29, 2024; previously CFO at Candel Therapeutics, Akebia, and Saniona.
All 6 evaluable patients treated with TSC-100 or TSC-101 achieved complete donor chimerism and MRD negativity; none of 4 control-arm patients achieved these endpoints.
TScan Therapeutics appoints R. Keith Woods to Board of Directors, effective immediately
Woods appointed as Class II director, serving on Audit and Compensation Committees.
TScan Therapeutics reports Q3 2023 net loss of $23.0M; cash runway into 2026
Net loss $23.0M in Q3 2023 vs $16.2M in Q3 2022; revenue $3.9M (up from $3.4M) from collaboration.
TScan Q2 net loss $24M, cash $208.8M; heme and solid tumor trials advancing
Net loss of $24.0M in Q2 2023, vs $15.1M in Q2 2022; revenue $3.1M (down from $4.1M).
Brian Silver resigned as CFO, effective July 21, 2023; CEO Gavin MacBeath named interim Principal Financial Officer.
TScan CFO Brian Silver to step down effective July 21, 2023
CFO and Treasurer Brian Silver resigns, effective July 21, 2023, to join an advisory firm in New York.
TScan shareholders approve 7.5M share increase to 2021 equity plan; options granted to executives
Stockholders approved Plan Amendment increasing authorized shares by 7,500,000 to 10,778,048 at June 13 annual meeting.
TScan Therapeutics appoints Gavin MacBeath as permanent CEO with increased compensation
Gavin MacBeath, Ph.D., appointed CEO and Class I Director effective May 24, 2023; previously acting CEO since March 2023.
TScan Therapeutics prices $140M public offering of common stock and pre-funded warrants
Gross proceeds of ~$140M from 22.99M shares at $2.00/share and 47.01M pre-funded warrants at $1.9999 each.
TScan reports preliminary Phase 1 data for TSC-100/101; TSC-101 advances to Dose Level 2
TSC-101 in high-risk MDS patient: 100% donor chimerism, no p53 mutation detected (sensitivity 0.01%), no DLTs.
TScan enters ATM equity offering with Wedbush, up to 2% commission
Entered Sales Agreement with Wedbush Securities for at-the-market issuance of common stock.
TScan reports Q1 net loss $22.6M; Amgen partnership adds $30M upfront, extends cash runway
Net loss $22.6M vs $16.2M in Q1 2022; revenue $6.8M, up from $3.0M on Novartis collaboration wind-down.
TScan enters $30M upfront collaboration with Amgen to identify Crohn's disease T-cell targets
TScan receives $30M upfront; eligible for over $500M in development and commercial milestone payments.
TScan Therapeutics adds Dr. Barbara Klencke to board and promotes three to SVP
Dr. Barbara Klencke appointed to board effective April 6, 2023; granted option for 9,146 shares vesting over 36 months.
TScan CEO David Southwell steps down; Gavin MacBeath named acting CEO
David Southwell resigned as CEO, President, and Board member effective March 27, 2023; no disagreement with company.
TScan Therapeutics reports Q4 net loss of $18.7M; cash $120M funds operations into Q2 2024
Q4 2022 net loss $18.7M vs $14.2M in Q4 2021; FY2022 net loss $66.2M vs $48.6M.
In connection with the Strategic Reorganization, effective as of September 2, 2026 (the “Effective Date”), the employment of Jason A. Amello, the Company’s Chief Financial Officer, and Chrystal Louis, M.D., MPH, the Company’s Chief Medical Officer, was terminated.
In connection with the Strategic Reorganization, effective as of September 2, 2026 (the “Effective Date”), the employment of Jason A. Amello, the Company’s Chief Financial Officer, and Chrystal Louis, M.D., MPH, the Company’s Chief Medical Officer, was terminated.
As of the Effective Date, Gavin MacBeath, Ph.D., the Company’s Chief Executive Officer, assumed the duties of the principal financial officer and principal accounting officer of the Company.
Current member of the Board, Stephen Biggar, M.D., Ph.D., assumed the role of Chairman of the Board, effective as of the Effective Date.
On June 12, 2024 (the “Effective Date”), after the conclusion of the 2024 Annual Meeting of Stockholders (the “Annual Meeting”) of TScan Therapeutics, Inc. (the “Company”), Timothy Barberich, a member and Chairman of the Board of Directors (the “Board”) of the Company, tendered his resignation from the Board and Chairman position thereof, effective immediately.
On June 12, 2024, the Board appointed Garry Nicholson to the Board, effective as of the Effective Date.
On January 29, 2024, TScan Therapeutics, Inc. (the “Company”) announced the appointment of Jason A. Amello as Chief Financial Officer, which was approved by the Board of Directors of the Company on January 24, 2024, effective January 29, 2024 (the “Start Date”).
On December 6, 2023, the Board of Directors (the “Board”) of TScan Therapeutics, Inc. (the “Company”) appointed R. Keith Woods, to the Board, effective December 6, 2023.
replacing Brian Silver, who had previously announced his resignation as Chief Financial Officer of the Company effective July 21, 2023.
appointed Leiden Dworak as Principal Accounting Officer of the Company, effective July 21, 2023
appointed Gavin MacBeath, Ph.D., as the interim Principal Financial Officer of the Company, effective July 21, 2023
On June 27, 2023, Mr. Brian Silver informed TScan Therapeutics, Inc. (the “Company”) of his intent to step down from his roles as Chief Financial Officer and Treasurer of the Company, effective July 21, 2023.
Max materiality 0.90 · Median 0.60 · Most common event other_material