Ardelyx CLO and CMO resign effective Dec 31; interim CMO appointed

ARDELYX, INC.

Elizabeth Grammer resigns as Chief Legal and Administrative Officer effective Dec 31, 2025; will serve as General Counsel then Senior Advisor for 24 months.
Edward Conner resigns as CMO effective Dec 31, 2025 for personal reasons; Dr. Laura Williams appointed interim CMO.
Grammer transition agreement: retains base salary, target bonus 45% for 2025, no ongoing bonus as advisor; equity continues vesting.
Laura Williams, former CMO and current Chief Patient Officer, serves as interim CMO until permanent hire.

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