FibroBiologics preclinical data: HDF spheroids cut psoriasis severity 35% in mice

FibroBiologics, Inc.

Presented at 2024 Keystone Symposia on Systemic Autoimmune and Autoinflammatory Diseases.
Single IV dose of HDF spheroids reduced average PASI score by 35% (p<0.0001) in IMQ-induced psoriasis mouse model.
Spheroids also ameliorated IMQ-induced spleen enlargement and normalized lymphocyte and monocyte counts.
In vitro, HDFs inhibited TNF-α and IL-17 and suppressed dendritic cell maturation via CD40/CD80/CD86 downregulation.
Company holds 150+ issued/pending patents; data supports IND-enabling studies for early-discovery psoriasis program.

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