Telomir-1 reduces DNA methylation of CASP8 and GSTP1 in aggressive prostate cancer model

Telomir Pharmaceuticals, Inc.

Telomir-1 decreased DNA methylation of CASP8 (apoptosis) and GSTP1 (detoxification) genes at Day 21, vs vehicle and chemo.
Combination of Telomir-1 and chemo showed lower methylation than chemo alone, suggesting potentiation of epigenetic effects.
Rapamycin showed initial methylation reduction at Day 10 but rebounded by Day 21; Telomir-1 showed sustained progressive decrease.
Data derived from mice bearing human aggressive prostate tumors; preclinical, not yet in humans.

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